The action takes place in the production of an entirely new universe, with niewidzianymi earlier figures. Individual countries on Earth have formed an alliance of United Nations Space Alliance to jointly set out to conquer the solar system. Unfortunately, as is usually the case, some people are opposed to international cooperation and that of them formed the organization Settlement Defense Front, which unleashed a big war with the UNSA. Players take the captain Reyes - pilot Tier 1 Special Operations, who took command of a powerful warship Retribution and, together with his crew must put an SDF.
The story takes the player to 2065, ie 40 years after the drone attack organized by Raul Menendez in the previous part of the cycle. To prevent ever more into a similar situation, the world decided to create a special defense system. Unfortunately, no one predicted the other dangers that led humanity to the brink of chaos - climate change, ending with raw materials and ideological conflict concerning genetic modifications and implants completely divided society and became a hotbed of ever bloodier wars.